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Crizanlizumab reduces priapic events in men with sickle cell disease

Crizanlizumab was associated with a halved likelihood of priapic events in treated patients with sickle-cell priapism, according to results from a phase 2 trial. In new data from the SPARTAN trial presented at the 2022 American Society of Hematology (ASH) annual meeting in New Orleans last week, a team of American researchers observed that the …

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A new 'heart attack on a chip' could serve as a test bed for developing personalized drugs

A new ‘heart attack on a chip’ could serve as a test bed for developing personalized drugs

Researchers from the Alfred E. Mann Department of Biomedical Engineering at the University of Southern California have developed a “heart attack on a chip,” a device that could one day serve as a test bed for developing new heart drugs and even personalized drugs. “Our device replicates some key features of a heart attack in …

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Less than 5% human effort: Reflections on the role of automation in cell and gene therapy

Less than 5% human effort: Reflections on the role of automation in cell and gene therapy

“Automation” means different things to different people. To me, this word primarily means “tasks completed with minimal human interaction” – less than 5%, to put a number. In automation, more than 95% of the tasks to be performed are performed by a non-human system, especially tasks that span several days, such as cell culture. An …

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